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Serpera  Bone  Marrow  Aspirate Concentrate

TFDA Medical Device Manufacturing No. 007571

  1. The concentration ratio of nucleated cells in BMAC can be more than 11 times higher than in BMA.

  2. We offer products in different specifications according to treatment needs.

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High nucleated cells concentration
( >11X)

Various specifications
( 10 / 15 / 40ml )

Product Specifications

Product Description

Bone Marrow Aspirate Concentrate (BMAC) is obtained from a patient's own bone marrow by centrifugation, resulting in the collection of free mesenchymal stemcells, nucleated cells, platelets, and anti-inflammatory substances. Mesenchymal stem cells within the nucleated cells have the capacity to differentiate into muscle, bone, and cartilage cells, releasing various growth factors that stimulate tissue regeneration in conditions such as osteonecrosis, tendon injuries, and cartilage damage. Abundant platelets in BMAC also release the growth factors they contain, promoting cell proliferation, facilitating blood vessel formation, and reducing inflammatory responses, thereby assisting in tissue repair. An anti-inflammatory substance, Interleukin-1 receptor antagonist (IL-1 Ra), effectively blocks the binding of inflammatory substances to their receptors, resulting in a reduction of pain and inflammation in damaged tissues.

The Serpera Bone Marrow Cell Separator employs an innovative one-step centrifugation method, utilizing the density gradient centrifugation based on the difference in density between the gel inside the separator and the blood. This technology enables the formation of a barrier between nucleated cells within the bone marrow and red blood cells, effectively recovering nucleated cell sand platelets from whole blood while simultaneously reducing the residual red blood cell content in the bone marrow concentrate. The Serpera Bone Marrow Cell Separator can provide various specifications based on the treatment needs of patients, making it convenient for therapeutic use.

Product Performance

Fig1. Nucleated Cell Count Statistics in CBC Machine Testing.

BMA (3 cell / field)

BMAC (35 cell / field)

Fig2.Smear Bone Marrow Aspirate (BMA) vs. Bone Marrow Aspirate Concentrate (BMAC)

The comparison of nuclear cell concentration between bone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMAC) prepared using the Serpera bone marrow cell separator, as tested on a CBC machine, showed that the nuclear cell concentration in the BMAC (259 x 10^3 per /ml) was more than 11 times higher than that in the concentrated BMA. Subsequent staining of smears (as shown in Fig. 2) confirmed results consistent with the CBC findings.

Fig.3 The difference between platelets in bone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMAC)

Comparison of Platelet Concentration in Bone Marrow Aspirate (BMA) and Bone Marrow Aspirate Concentrate (BMAC):

Using the Serpera bone marrow cell separator, the platelet concentration in BMAC is significantly higher compared to the original BMA. In the experiment, the platelet concentration in BMAC was measured at 1204 x 10^3 per/μl, which represents an increase in concentration of over 11 times compared to the non-concentrated bone marrow aspirate.

BMAC is a concentrated form of BMA. During the preparation process using devices like the Serpera bone marrow cell separator, BMA is processed to remove excess red blood cells and other components, leaving behind a higher concentration of platelets in BMAC. This experiment demonstrates the effectiveness of the Serpera bone marrow cell separator in concentrating both nucleated cells and platelets from the bone marrow aspirate, resulting in a highly concentrated BMAC.

Product Preparation

Serpera - BMAC

Image positioning.

Inject into Serpera BMAC tube.

Draw out.

Nucleated cell isolation.

Cell separation completes extraction.

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